Mild Hyperhomocyst(e)inemia

Prevalence of familial mild hyperhomocysteinemia.

Previous studies have shown that elevated basal homocysteine levels are correlated among family members of patients with coronary vascular disease and juvenile venous thrombosis. This suggests the possibility of the presence of inherited basal mild hyperhomocysteinemia (mHH). We studied homocysteine levels, fasting as well as after methionine load, among 96 family members of 21 post-load hyperh...

Mild hyperhomocysteinemia and arterial occlusive disease.

Why should mild hyperhomocysteinemia be responsible for CAD?

Responsible for CAD? To the Editor: Since June 1997, we have measured homocysteine (Hcy) in 42 patients with cervical artery dissection (CAD), and so far, the mean Hcy level has been 17.8 9.1 mol/L. This finding confirms our previous ones demonstrating that mild hyperhomocysteinemia is associated with CAD.1 This result was confirmed by another group.2 It is still unknown whether hyperhomocystei...

Association of mild hyperhomocysteinemia with aortic calcification in hypercholesterolemic patients.

Homocysteine is considered to be an independent risk factor for atherosclerosis. Experimental animal models of hyperhomocysteinemia show aortic calcification, suggesting that this disorder is associated with aortic calcification in humans. A total of 28 patients with hyperlipidemia were enrolled into this study. The degree of aortic calcification at the level of the bifurcation and 1 cm proxima...

High prevalence of mild hyperhomocysteinemia and folate, B

Objective: To find out the prevalence of hyperhomocysteinemia, and deficiencies of folate, vitamin B6 and vitamin B12 in an urban population in Karachi, Pakistan. Methodology: In a pre and post experimental study, eight hundred and seventy-two apparently healthy adults (aged 18-60 years; 355 males and 517 females) were recruited from a low-income urban locality in East of Karachi from February ...